If diazepam should be to be coupled with other psychotropic agents or anticonvulsant medicines, mindful consideration needs to be provided towards the pharmacology with the agents to become utilized - specifically with known compounds which will potentiate the action of diazepam, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants (see DRUG INTERACTIONS).
ベンゾジアゼピンに対して精神的依存の疑いのある人に対しては、非常に緩やかに断薬しなければならない。まれながら、投与が長時間にわたっている場合、離脱症状が致命的となることがある。依存の形成が治療によるものか乱用によるものかを慎重に判断しなければならない。
Benzodiazepines which include diazepam are lipophilic and speedily penetrate membranes, Hence promptly cross about in the placenta with considerable uptake on the drug. Utilization of benzodiazepines like diazepam in late pregnancy, Particularly superior doses, can lead to floppy toddler syndrome.[sixty three] Diazepam when taken late in pregnancy, over the 3rd trimester, triggers a definite risk of a significant benzodiazepine withdrawal syndrome during the neonate with signs or symptoms including hypotonia, and reluctance to suck, to apnoeic spells, cyanosis, and impaired metabolic responses to chilly tension.
Labor or Shipping and delivery Exclusive treatment must be taken when diazepam is made use of during labor and supply, as higher solitary doses may perhaps create irregularities from the fetal heart rate and hypotonia, poor sucking, hypothermia, and average respiratory melancholy within the neonates.
The anticonvulsant Attributes of diazepam along with other benzodiazepines may be partially or entirely as a consequence of binding to voltage-dependent sodium channels instead of GABAA receptors.
ジアゼパムはまれに、フェニトイン（アレビアチン）の代謝を阻害し、その作用（と副作用）を増強する。
har självmordstankar har epilepsi eller tidigare har haft krampanfall har nedsatt lever eller njurfunktion
Jangan berkendara atau melakukan click here aktivitas lain yang memerlukan kewaspadaan setelah menggunakan diazepam, karena obat ini bisa menyebabkan pusing dan kantuk.
Normal If diazepam is always to be combined with other psychotropic agents or anticonvulsant medications, very careful consideration needs to be supplied to the pharmacology in the agents for being utilized - particularly with recognized compounds that could potentiate the action of diazepam for instance phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants (see Drug Interactions).
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Diazepam umumnya berfungsi untuk menangani kejang dan melemaskan otot yang kaku atau tegang. Obat ini juga digunakan untuk menenangkan pasien sebelum operasi dan menangani gangguan kecemasan berat. Diazepam juga bisa dimanfaatkan untuk menangani gejala sindrom putus alkohol.
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In individuals presently getting an opioid analgesic, prescribe a reduced initial dose of diazepam than indicated during the absence of an opioid and titrate depending on scientific reaction. If an opioid is initiated inside of a client previously having diazepam, prescribe a decreased initial dose in the opioid and titrate centered on clinical response.
If this drug is applied for the duration of pregnancy, or When the individual becomes Expecting whilst taking this drug, the individual should be apprised from the probable hazard into the fetus. Patients should also be advised that should they grow to be pregnant during therapy or intend to grow to be pregnant they need to communicate with their medical professional in regards to the desirability of discontinuing the drug.